p16Ink4a in Melanocyte Senescence and Differentiation
نویسندگان
چکیده
منابع مشابه
p16 in Melanocyte Senescence and Differentiation
Background: The Ink4a-Arf tumor suppressor locus encodes two growth inhibitors, p16 and Arf, both of which are also implicated as effectors in cellular senescence. Because human germline defects in the INK4A-ARF locus are associated with familial melanoma, melanocytes may have unusual INK4A-ARF functions or controls of cell senescence. Because senescence is believed to be an anticancer mechanis...
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senescence is the activation of the INK4/ARF locus, which is epigenetically regulated and under tight control of the Polycomb group (PcG) Trithorax group (TrxG) proteins [1]. In proliferating cells, the locus is silenced by Polycomb repressive complexes (PRCs), and the chromatin is enriched in H3K27me3 [2]. Upon senescence triggers, PRCs are displaced and the repressive H3K27me3 mark is removed...
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Telomere attrition in primary human fibroblasts induces replicative senescence accompanied by activation of the p53 and p16(INK4a)/RB tumor suppressor pathways. Although the contribution of p53 and its target, p21, to telomere-driven senescence have been well established, the role of p16(INK4a) is controversial. Attempts to dissect the significance of p16(INK4a) in response to telomere shorteni...
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Pigmentation has long been a favourite and easily used marker in the genetics of diverse organisms. Mammalian integumental pigments are melanins, synthesized by melanocytes in the epidermis and hair bulbs. Our understanding of mammalian pigmentation genes has been advanced significantly in the last few years (Hearing and Jim6nez, 1989), partly by the advent of methods for the culture and immort...
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ژورنال
عنوان ژورنال: CancerSpectrum Knowledge Environment
سال: 2002
ISSN: 1460-2105
DOI: 10.1093/jnci/94.6.446